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HOT TOPICS IN VIRAL HEPATITIS: Issue 8, 2007
New antivirals in hepatitis C
New inhibitors of the HCV life cycle
Roniel Cabrera, David R. Nelson
Correspondence to:
Roniel Cabrera - MD, MS Assistant Professor of Medicine Section of Hepatobliary Diseases University of Florida Shands Hospital Gainesville, Florida, USA E-mail: cabrer@medicine.ufl.edu
Summary
- OVERVIEW OF THE HCV LIFE CYCLE
- Cell infection
- Replication
- Assembly and secretion
- INHIBITORS OF CELL ENTRY
- INHIBITORS OF REPLICATION: IRES (OLIGONUCLEOTIDES), POSTTRANSLATIONAL PROCESSING (PROTEASE) AND TRANSCRIPTION (POLYMERASE) INHIBITORS
- Oligonucleotides
- Protease inhibitors
- Polymerase inhibitors
- Inhibitors of viral assembly
- CONCLUSION
- REFERENCES
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