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HOT TOPICS IN VIRAL HEPATITIS: Issue 8, 2007
New antivirals in hepatitis C
Antifibrosing agents
Fabio Marra
Correspondence to:
Fabio Marra - MD, PhD Associate Professor of Medicine Department of Internal Medicine University of Florence Florence, Italy E-mail: f.marra@dmi.unifi.it
Summary
- CELLULAR EFFECTORS OF FIBROGENESIS
- HSC 'ACTIVATION' AS A CENTRAL EVENT IN FIBROGENESIS
- IDENTIFICATION OF ANTIFIBROSING AGENTS
- ANTIFIBROTIC STRATEGIES
- Limitation of parenchymal damage
- Interference with liver inflammation
- Antioxidants
- Limitation of extracellular matrix production
- Inhibition of hepatic stellate cell activation
- Interference with the activated phenotype of HSC
- Adipokines
- Apoptosis of fibrogenic cells
- Stimulation of fibrolysis
- HSC targeting
- Herbal medicine
- OBSTACLES TO THE DEVELOPMENT OF ANTIFIBROTIC DRUGS
- CONCLUSION
- REFERENCES
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