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HOT TOPICS IN ONCOLOGY: Issue 3, 2008
Cervical cancer
Management of cervical cancer
Jonathan S. Berek, Nita K. Lee
Correspondence to:
Jonathan S. Berek - MD, MMS
Professor and Chair
Department of Obstetrics and Gynecology
Division of Gynecologic Oncology
Stanford University School of Medicine
Stanford Cancer Center
Stanford, CA, USA
E-mail: jberek@stanford.edu
DOI: 10.4147/HTO-080315

Abstract


Article abstract Cervical cancer remains a significant cause of morbidity and mortality throughout the world. The diagnosis and accurate staging of a new cervical cancer is critical because appropriate treatment with surgery and/or radiation and chemotherapy is stage-specific. General principles of treatment for cervical cancer must include adequate treatment of the primary tumor and potential sites of metastatic disease such as the parametrium or regional lymph nodes.In the first part of this article, the main issue regarding clinical staging and the role of newer imaging technologies and surgical staging are described. In the second part, treatment options and concerns for patients with cervical cancer are reviewed, according to stage. The authors describe the best management options for microinvasive, early stage, locally advanced, and centralized recurrent disease; metastatic advanced disease; and disseminated recurrent disease. Finally, special considerations are dedicated to cervical cancer in pregnancy and to the treatment of nonsquamous cell histologic types.

Summary


  • EPIDEMIOLOGY AND INCIDENCE OF CERVICAL CANCER
  • DIAGNOSIS OF CERVICAL CANCER
  • STAGING OF CLINICAL CANCER
  • Clinical Staging
  • Surgical staging
  • TREATMENT FOR CERVICAL CANCER
  • Microinvasive cervical cancer (stages IA1 and IA2)
  • Early stage cervical cancer (stages IB1, IIA)
  • Surgical options
  • Adjuvant postoperative treatment
  • Early stage cervical cancer (stages IB2, bulky IIA)
  • Chemoradiation
  • Locally advanced stage cervical cancer (stages IIB, III, IVA)
  • Centralized recurrent disease
  • Metastatic advanced disease/ disseminated recurrent disease
  • SPECIAL CONSIDERATIONS IN CERVICAL CANCER MANAGEMENT
  • Cervical cancer in pregnancy
  • Nonsquamous cell histologic types
  • Adenocarcinoma of the cervix
  • Neuroendocrine tumors of the cervix
  • Sarcomas of the cervix
  • REFERENCES

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